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Its underlying mechanisms are multifaceted, encompassing genetic variations, environmental influences, cerebral artery constriction, abnormalities in monoamine neurotransmitters, oxidative stress, mitochondrial disturbances, the involvement of calcitonin gene-related peptide (CGRP), neurogenic inflammation, and broader neuroinflammation (6)

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Specialized pro-resolving mediators (SPMs) are a class of PUFA-derived lipid mediators (49)

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Any unused active ingredient should be discarded.